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Transcription Termination Factor, RNA Polymerase II (TTF2)

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HuF2; Lodestar homolog; RNA polymerase II termination factor; Transcription release factor 2

Transcription Termination Factor, RNA Polymerase II (TTF2)
CCC P569
HGNC 12398
MGI 1921294
PubMed 15467445
RGD 1309145
UniProt Q9UNY4
Wiki TTF2
TTF2 has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.The deduced 990-amino acid TTF2 protein shares 43% amino acid sequence identity with Drosophila factor 2. These proteins contain 7 motifs found in helicase superfamilies 1 and 2; 7 additional motifs shared only by SWI2/SNF2 family members; and 3 conserved motifs and a nuclear localization signal that are not conserved among the SWI2/SNF2 family. Similar to Drosophila factor 2, recombinant human TTF2 displayed a strong double-stranded DNA-dependent ATPase activity that was inhibited by single-stranded DNA and exhibited RNA polymerase II termination activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Termination Factor, RNA Polymerase II (TTF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Termination Factor, RNA Polymerase II (TTF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Termination Factor, RNA Polymerase II (TTF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Termination Factor, RNA Polymerase II (TTF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Termination Factor, RNA Polymerase II (TTF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Termination Factor, RNA Polymerase II (TTF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Termination Factor, RNA Polymerase II (TTF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Termination Factor, RNA Polymerase II (TTF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Termination Factor, RNA Polymerase II (TTF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Termination Factor, RNA Polymerase II (TTF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Termination Factor, RNA Polymerase II (TTF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Termination Factor, RNA Polymerase II (TTF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Termination Factor, RNA Polymerase II (TTF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Termination Factor, RNA Polymerase II (TTF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Termination Factor, RNA Polymerase II (TTF2) ELISA Kit Customized Service Offer
  1. "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member."J. Biol. Chem. 273:25541-25544(1998) [PubMed] [Europe PMC] [Abstract]
  2. "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing."Biochem. Biophys. Res. Commun. 308:793-801(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer."J. Biol. Chem. 274:24779-24786(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation."Mol. Cell 14:375-385(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]