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Timeless Homolog (TIM)

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Timeless Homolog (TIM)
CCC P585
HGNC 11813
MGI 1321393
PubMed 23173913
RGD 620939
UniProt Q9UNS1
Wiki TIM

Cellular pacemakers located in the suprachiasmatic nucleus (SCN) of the anterior hypothalamus control circadian rhythms. In Drosophila, a central clock mechanism involves the dynamic regulation of 2 genes, 'period' (per;) and 'timeless' (tim), which physically interact and participate in an intracellular transcriptional/translational feedback loop.The predicted 1,208-amino acid human protein is 84% identical to mouse Tim. The mammalian proteins share 4 regions of homology with Drosophila tim, including regions involved in nuclear localization, protein-protein interaction with PER, and cytoplasmic localization. Northern blot analysis revealed that TIM was expressed as a 4.5-kb mRNA in all human tissues tested, with the highest levels in placenta, pancreas, thymus, and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Timeless Homolog (TIM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Timeless Homolog (TIM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Timeless Homolog (TIM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Timeless Homolog (TIM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Timeless Homolog (TIM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Timeless Homolog (TIM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Timeless Homolog (TIM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Timeless Homolog (TIM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Timeless Homolog (TIM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Timeless Homolog (TIM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Timeless Homolog (TIM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Timeless Homolog (TIM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Timeless Homolog (TIM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Timeless Homolog (TIM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Timeless Homolog (TIM) ELISA Kit Customized Service Offer
  1. "Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1."FEBS Lett. 441:427-431(1998) [PubMed] [Europe PMC] [Abstract].
  2. "Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription."Neuron 21:1101-1113(1998) [PubMed] [Europe PMC] [Abstract] and Skin.
  3. "Coupling of human circadian and cell cycles by the timeless protein."Mol. Cell. Biol. 25:3109-3116(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function."Proc. Natl. Acad. Sci. U.S.A. 103:18143-18147(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint."J. Biol. Chem. 282:2729-2740(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors."J. Mol. Biol. 366:36-52(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement."Mol. Cell. Biol. 27:3131-3142(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The many facets of the Tim-Tipin protein families' roles in chromosome biology."Cell Cycle 9:700-705(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Timeless makes some time for itself."Cell Cycle 10:2254-2254(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock."PLoS ONE 8:E56623-E56623(2013) [PubMed] [Europe PMC] [Abstract]
  19. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]