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Serine/Threonine Kinase 10 (STK10)

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LOK; Lymphocyte-oriented kinase

Serine/Threonine Kinase 10 (STK10)
CCC P654
HGNC 11388
MGI 1099439
PubMed 23842845
RGD 3779
UniProt O94804
Wiki STK10
STK10encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
These results established STK10 as a new marker of human chromosome 5 to define the syntenic boundary of human chromosomes 5 and 16 on mouse chromosome 11.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 10 (STK10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 10 (STK10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 10 (STK10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 10 (STK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 10 (STK10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 10 (STK10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 10 (STK10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 10 (STK10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 10 (STK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 10 (STK10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 10 (STK10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 10 (STK10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 10 (STK10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 10 (STK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 10 (STK10) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues."Immunogenetics 49:369-375(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells."Biochem. J. 363:175-182(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue."J. Biol. Chem. 278:18221-18228(2003) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 106:4707-4712(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Off-target serine/threonine kinase 10 inhibition by erlotinib enhances lymphocytic activity leading to severe skin disorders."Mol. Pharmacol. 80:466-475(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites."EMBO J. 27:704-714(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults." Genes Chromosomes Cancer 45:42-46(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]