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Small Muscle Protein, X-Linked (SMPX)

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SRMX; Stretch-responsive skeletal muscle protein

Small Muscle Protein, X-Linked (SMPX)
CCC P671
HGNC 11122
MGI 1913356
PubMed 16095948
RGD 69233
UniProt Q9UHP9
A wide range of techniques, including differential display, the 2-hybrid system, exon trapping, and reciprocal probing, have been applied to isolate human genes for basic functional analysis or as candidates for genetic disorders. In more recent times, large scale sequencing of both the human genome and a growing number of EST libraries has provided tools to improve gene identification.The orthologous mouse and rat Smpx genes could be aligned and confirmed by complete sequencing of additional SMPX-related clones obtained by library screening. The human and rodent SMPX genes encode proteins of 88 to 86 and 85 amino acids, respectively. The authors found that the SMPX gene consists of 5 exons and 4 introns, comprising together 52.1 kb. SMPX is preferentially and abundantly expressed in heart and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Muscle Protein, X-Linked (SMPX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Muscle Protein, X-Linked (SMPX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Muscle Protein, X-Linked (SMPX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Muscle Protein, X-Linked (SMPX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Muscle Protein, X-Linked (SMPX) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Muscle Protein, X-Linked (SMPX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Muscle Protein, X-Linked (SMPX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Muscle Protein, X-Linked (SMPX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Muscle Protein, X-Linked (SMPX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Muscle Protein, X-Linked (SMPX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Muscle Protein, X-Linked (SMPX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Muscle Protein, X-Linked (SMPX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Muscle Protein, X-Linked (SMPX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Muscle Protein, X-Linked (SMPX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Muscle Protein, X-Linked (SMPX) ELISA Kit Customized Service Offer
  1. "Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein."Hum. Genet. 105:506-512(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel stretch-responsive skeletal muscle gene (Smpx)."Genomics 72:260-271(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Nonsense mutations in SMPX, encoding a protein responsive to physical force, result in X-chromosomal hearing loss."Am. J. Hum. Genet. 88:621-627(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Next-generation sequencing identifies mutations of SMPX, which encodes the small muscle protein, X-linked, as a cause of progressive hearing impairment."Am. J. Hum. Genet. 88:628-634(2011) [PubMed] [Europe PMC] [Abstract]
  8. "A novel deletion in SMPX causes a rare form of X-linked progressive hearing loss in two families due to a founder effect."Hum. Mutat. 34:66-69(2013) [PubMed] [Europe PMC] [Abstract]