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SH3 Domain GRB2 Like Protein 3 (SH3GL3)

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SH3D2C; SH3P13; CNSA3; EEN-B2; Endophilin-3; Endophilin A3; SH3 domain protein 2C; SH3 domain-containing GRB2-like protein 3

SH3 Domain GRB2 Like Protein 3 (SH3GL3)
CCC P690
HGNC 10832
MGI 700011
PubMed 23187129
RGD 620578
UniProt Q99963
Wiki SH3GL3
The Src homology 3 domain (SH3) is an evolutionarily conserved, 50- to 60-amino acid module carried by intracellular proteins involved in the transduction of signals for cell polarization, motility, enzymatic activation, and transcriptional regulation. The SH3 drives protein-protein interactions through binding to proline-rich ligands. Coimmunoprecipitations and immunofluorescence studies revealed that SH3GL3 and HDex1p colocalize in transfected COS cells. Additionally, an anti-SH3GL3 antibody was able to coimmunoprecipitate the full-length huntingtin from an HD human brain extract. The characteristics of the interaction between SH3GL3 and huntingtin and the colocalization of the 2 proteins suggested that SH3GL3 could be involved in the selective neuronal cell death in HD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain GRB2 Like Protein 3 (SH3GL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain GRB2 Like Protein 3 (SH3GL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain GRB2 Like Protein 3 (SH3GL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain GRB2 Like Protein 3 (SH3GL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain GRB2 Like Protein 3 (SH3GL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain GRB2 Like Protein 3 (SH3GL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain GRB2 Like Protein 3 (SH3GL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain GRB2 Like Protein 3 (SH3GL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain GRB2 Like Protein 3 (SH3GL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain GRB2 Like Protein 3 (SH3GL3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain GRB2 Like Protein 3 (SH3GL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain GRB2 Like Protein 3 (SH3GL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain GRB2 Like Protein 3 (SH3GL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain GRB2 Like Protein 3 (SH3GL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain GRB2 Like Protein 3 (SH3GL3) ELISA Kit Customized Service Offer
  1. "A novel SH3-containing human gene family preferentially expressed in the central nervous system."Genomics 41:427-434(1997) [PubMed] [Europe PMC] [Abstract]
  2. "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates."Mol. Cell 2:427-436(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity."J. Biol. Chem. 274:32001-32007(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance."Endocrinology 146:3757-3764(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking."Cell. Signal. 20:1725-1739(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis."Eur. J. Cell Biol. 88:509-520(2009) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of BAR domain of endophilin-III."Submitted (FEB-2009) to the PDB data bank