Sex Comb On Midleg Like Protein 1 (SCML1)

The SCML1 gene spans 18 kb and contains 6 exons. It is transcribed from telomere to centromere. Northern blot analysis detected a major approximately 3-kb SCML1 transcript in all human adult and fetal tissues tested, with the highest expression in adult skeletal muscle and heart and fetal liver.

The predicted 208-amino acid SCML1 protein contains 2 domains that are present in PcG gene products and their mammalian homologs. In addition to the Scm gene product, the SCML1 protein shares high sequence similarity with the Drosophila polyhomeotic (Ph) gene product, mouse Mph1, and human EDR1 and EDR2, all of which are PcG members or homologs. The authors identified cDNAs representing alternatively spliced SCML1 transcripts.