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RAD23 Homolog A (RAD23A)

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HHR23A; UV excision repair protein RAD23 homolog A

RAD23 Homolog A (RAD23A)
CCC P752
HGNC 9812
MGI 105126
PubMed 7851894
RGD 1309899
UniProt P54725
Wiki RAD23A
RAD23A is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. The 125-kD subunit represented the previously reported XPC gene product, which represents the human homolog of the nucleotide excision repair (NER) gene RAD4 of Saccharomyces cerevisiae.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD23 Homolog A (RAD23A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD23 Homolog A (RAD23A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD23 Homolog A (RAD23A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD23 Homolog A (RAD23A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD23 Homolog A (RAD23A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD23 Homolog A (RAD23A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD23 Homolog A (RAD23A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD23 Homolog A (RAD23A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD23 Homolog A (RAD23A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD23 Homolog A (RAD23A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD23 Homolog A (RAD23A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD23 Homolog A (RAD23A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD23 Homolog A (RAD23A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD23 Homolog A (RAD23A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD23 Homolog A (RAD23A) ELISA Kit Customized Service Offer
  1. "Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23."EMBO J. 13:1831-1843(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair."J. Virol. 71:9732-9742(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity."Mol. Cell. Biol. 17:6924-6931(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome."J. Biol. Chem. 274:28019-28025(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B."Hum. Mol. Genet. 9:1795-1803(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Ubiquitin recognition by the DNA repair protein hHR23a."Biochemistry 42:13529-13535(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains."J. Biol. Chem. 278:8951-8959(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A."J. Mol. Biol. 341:1367-1379(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B."FEBS Lett. 580:3401-3408(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Ubiquitin receptor proteins hHR23a and hPLIC2 interact."J. Mol. Biol. 365:1093-1101(2007) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins."BMC Biochem. 9:4-4(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome."PLoS ONE 5:E11371-E11371(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr."Nat. Struct. Biol. 5:1042-1047(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr."Biochemistry 39:14103-14112(2000) [PubMed] [Europe PMC] [Abstract]
  24. "Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions."J. Mol. Biol. 319:1243-1255(2002) [PubMed] [Europe PMC] [Abstract]
  25. "Structural determinants for the binding of ubiquitin-like domains to the proteasome."EMBO J. 22:4634-4645(2003) [PubMed] [Europe PMC] [Abstract]
  26. "DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a."Proc. Natl. Acad. Sci. U.S.A. 100:12694-12699(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction."Protein Sci. 13:2370-2377(2004) [PubMed] [Europe PMC] [Abstract]
  28. "Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain."Mol. Cell 18:687-698(2005) [PubMed] [Europe PMC] [Abstract]