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Proteasome 26S Subunit, Non ATPase 10 (PSMD10)

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p28; Gankyrin; 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28

Proteasome 26S Subunit, Non ATPase 10 (PSMD10)
CCC P783
HGNC 9555
MGI 1858898
PubMed 9714768
RGD 620350
UniProt O75832
Wiki PSMD10
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
PSMD10 encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.The predicted 226-amino acid human p28 protein contains 5 ankyrin repeats, which are thought to function in protein-protein interactions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP783Hu01 Recombinant Proteasome 26S Subunit, Non ATPase 10 (PSMD10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP783Hu21 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 10 (PSMD10) WB; IHC; ICC; IP.
PAP783Hu01 Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 10 (PSMD10) WB; ICC; IHC-P; IHC-F; ELISA.
MAP783Hu23 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 10 (PSMD10) WB; IHC; ICC; IP.
MAP783Hu22 Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 10 (PSMD10) WB
Assay Kits SEP783Hu ELISA Kit for Proteasome 26S Subunit, Non ATPase 10 (PSMD10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 10 (PSMD10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 10 (PSMD10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 10 (PSMD10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 10 (PSMD10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 10 (PSMD10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome 26S Subunit, Non ATPase 10 (PSMD10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 10 (PSMD10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 10 (PSMD10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome 26S Subunit, Non ATPase 10 (PSMD10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome 26S Subunit, Non ATPase 10 (PSMD10) ELISA Kit Customized Service Offer
  1. "cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome."Gene 216:113-122(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
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  5. "Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas."Nat. Med. 6:96-99(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb."Biochemistry 41:3977-3983(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome."J. Biol. Chem. 277:10893-10902(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53."Cancer Cell 8:75-87(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export."Cell Res. 17:1020-1029(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones."Cell 137:914-925(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Involvement of the mitochondrial pathway in p53-independent apoptosis induced by p28GANK knockdown in Hep3B cells."Cytogenet. Genome Res. 125:87-97(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells."J. Clin. Invest. 120:2829-2841(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure-function relationship."Biochemistry 43:12152-12161(2004) [PubMed] [Europe PMC] [Abstract]
  16. "The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53."J. Biol. Chem. 279:1541-1545(2004) [PubMed] [Europe PMC] [Abstract]
  17. "X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma."Proteins 55:214-217(2004) [PubMed] [Europe PMC] [Abstract]