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PR Domain Containing Protein 7 (PRDM7)

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ZNF910; PFM4; PR domain zinc finger protein 7; Probable histone-lysine N-methyltransferase PRDM7

PR Domain Containing Protein 7 (PRDM7)
CCC P788
HGNC 9351
PubMed 17916234
UniProt Q9NQW5
Progressive diversification of paralogs after gene expansion is essential to increase their functional specialization. However, mode and tempo of this divergence remain mostly unclear. PRDM7 underwent major structural rearrangements that decreased the number of encoded Zn-Fingers and modified gene splicing. Through internal duplication and activation of a non-canonical splice site (GC-AG), PRDM7 can acquire a novel intron.
PRDM7 is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PR Domain Containing Protein 7 (PRDM7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PR Domain Containing Protein 7 (PRDM7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PR Domain Containing Protein 7 (PRDM7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PR Domain Containing Protein 7 (PRDM7) CLIA Kit Customized Service Offer
n/a ELISA Kit for PR Domain Containing Protein 7 (PRDM7) ELISA Kit Customized Service Offer
  1. "Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates."BMC Evol. Biol. 7:187-187(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The yin-yang of PR-domain family genes in tumorigenesis."Histol. Histopathol. 15:109-117(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]