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CCR4 NOT Transcription Complex Subunit 8 (CNOT8)

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POP2; CAF2; hCAF1; CALIF; PGK Promoter Directed Over Production; CAF1-like protein; CCR4-associated factor 8

CCR4 NOT Transcription Complex Subunit 8 (CNOT8)
CCC P793
HGNC 9207
MGI 1916375
PubMed 19605561
RGD 1306401
UniProt Q9UFF9
Wiki CNOT8
The deduced 293-amino acid human homolog of yeast CAF1 shares 75% amino acid sequence identity with human CAF1.Comparative analysis of the protein sequences of human CALIF, human CAF1, and yeast CAF1 revealed 34% overall identity between CALIF and yeast CAF1 and 35% identity between human CAF1 and yeast CAF1.
It cannot be determined from these numbers alone whether CALIF or human CAF1 is the true human ortholog of yeast CAF1. Both CALIF and human CAF1 are shorter than yeast CAF1, which contains an N-terminal extension of approximately 140 amino acids. CALIF can interact with yeast NOT1, an N-terminally truncated human NOT1 protein , human NOT3, and yeast CCR4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 8 (CNOT8) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 8 (CNOT8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 8 (CNOT8) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 8 (CNOT8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 8 (CNOT8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 8 (CNOT8) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 8 (CNOT8) ELISA Kit Customized Service Offer
  1. "The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome."Genomics 56:134-136(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits."Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway."J. Biol. Chem. 276:9640-9648(2001) [PubMed] [Europe PMC] [Abstract]
  8. "BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms."J. Cell Sci. 116:2929-2936(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Conservation of the deadenylase activity of proteins of the Caf1 family in human."RNA 11:487-494(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Human Ccr4-Not complexes contain variable deadenylase subunits."Biochem. J. 422:443-453(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation."Mol. Biol. Cell 20:3840-3850(2009) [PubMed] [Europe PMC] [Abstract]
  12. "CCR4-NOT deadenylates mRNA associated with complexes in human cells."Mol. Cell. Biol. 30:1486-1494(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex."PLoS ONE 7:E51331-E51331(2012) [PubMed] [Europe PMC] [Abstract]