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Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4)

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VPS15; p150; PI3-kinase p150 subunit; Phosphoinositide 3-kinase adaptor protein

Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4)
CCC P798
HGNC 8982
MGI 1922919
PubMed 18618715
RGD 1311809
UniProt Q99570
Wiki PIK3R4
In yeast, the vps15 gene product is a 150-kD serine/threonine kinase that forms a complex with a phosphatidylinositol 3-kinase, vps34 (PIK3C3); in human this complex is involved in protein trafficking. By screening a cDNA library, Panaretou et al. (1997) cloned the homolog of the yeast vps15 gene, which they termed p150. The p150 cDNA encodes a predicted polypeptide of 1,358 amino acids.
The amino acid sequence is 29.6% identical to that of yeast vps15 protein. Northern blot analysis revealed that the p150 gene is ubiquitously expressed as a 5.5-kb transcript. Panaretou et al. (1997) found that the p150 gene interacts with PIK3C3 in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 4 (PIK3R4) ELISA Kit Customized Service Offer
  1. "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.PtdIns 3-kinase complex."J. Biol. Chem. 272:2477-2485(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human VPS34 and p150 are Rab7 interacting partners."Traffic 4:754-771(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."Nat. Cell Biol. 11:385-396(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy."Mol. Cell. Biol. 33:3675-3688(2013) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]