≡

NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8)

[Edit]

PGIV; Complex I PGIV Subunit; NADH-ubiquinone oxidoreductase 19 kDa subunit; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8)
CCC P849
HGNC 7692
MGI 1915625
PubMed 21310150
RGD 1306283
UniProt P51970
Wiki NDUFA8
The NDUFA8 open reading frame includes 519 bp and encodes 172 amino acids. The human cDNA sequence shows 86.2% identity with the bovine sequence, whereas the human NDUFA8 amino acid sequence is 87.8% similar to its bovine counterpart. A multiple tissue blot revealed the highest NDUFA8 mRNA expression in human heart, skeletal muscle, and fetal heart. Mutation analysis of the NDUFA8 fibroblast cDNA in 20 patients with isolated enzymatic complex I deficiency in cultured skin fibroblasts revealed 2 polymorphisms, one within the open reading frame and the other in the 3-prime untranslated region of the NDUFA8 cDNA sequence. The allelic frequency of both polymorphisms were similar in controls and complex I-deficient patients.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 8 (NDUFa8) ELISA Kit Customized Service Offer
  1. "The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients."Hum. Genet. 103:557-563(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Renal cell carcinoma and normal kidney protein expression."Electrophoresis 18:599-604(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I."FEBS Lett. 585:737-743(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]