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Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B)

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N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb

Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B)
CCC P872
HGNC 7048
MGI 2143974
PubMed 10372966
RGD 1562836
UniProt Q9UQ53
Wiki MGAT4B
MGAT4B encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6 Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. The deduced 548-amino acid MGAT4B protein has a predicted type II membrane topology with a short N-terminal cytoplasmic tail. MGAT4A and MGAT4B share 62% amino acid sequence identity. Northern blot analysis detected a 2.7-kb MGAT4B transcript in all human tissues and cancer cell lines tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannosyl Alpha-1,3-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase Isozyme B (MGAT4B) ELISA Kit Customized Service Offer
  1. "A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment."Glycoconj. J. 15:1115-1123(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer."Biochem. Biophys. Res. Commun. 341:478-482(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes."Glycoconj. J. 23:473-480(2006) [PubMed] [Europe PMC] [Abstract]