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Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1)

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HsMAD1; MAD1; PIG9; TP53I9; TXBP181; Mitotic spindle assembly checkpoint protein MAD1; Mitotic checkpoint MAD1 protein homolog; Tax-binding protein 181

Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1)
CCC P874
HGNC 6762
MGI 1341857
PubMed 11423979
RGD 1596881
UniProt Q9Y6D9
Wiki Mad1
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.
MAD1L1 functions as a homodimer. It localizes to the centrosome during metaphase and to the spindle midzone and the midbody during anaphase and telophase. Expression of either Tax or a transdominant-negative MAD1L1 results in multinucleated cells, a phenotype consistent with a loss of MAD1L1 function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Polyclonal Antibody Customized Service Offer
Assay Kits SEP874Hu ELISA Kit for Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitotic Arrest Deficient 1 Like Protein 1 (MAD1L1) ELISA Kit Customized Service Offer
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  2. "Phosphorylation of human MAD1 by the BUB1 kinase in vitro."Biochem. Biophys. Res. Commun. 257:589-595(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5."Genomics 55:363-364(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
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  7. "Multiple tumor suppressor pathways negatively regulate telomerase."Cell 113:881-889(2003) [PubMed] [Europe PMC] [Abstract]
  8. "NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling."J. Biol. Chem. 279:20049-20057(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint."Genes Dev. 22:2926-2931(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator."J. Cell Biol. 184:647-657(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis."J. Biol. Chem. 285:10841-10849(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint."EMBO J. 21:2496-2506(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Characterization of MAD2B and other mitotic spindle checkpoint genes."Genomics 58:181-187(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers."Oncogene 18:7180-7183(1999) [PubMed] [Europe PMC] [Abstract]
  25. "Mutations in the mitotic check point gene, MAD1L1, in human cancers."Oncogene 20:3301-3305(2001) [PubMed] [Europe PMC] [Abstract]