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Neighbor Of BRCA1 Gene 1 (NBR1)

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M17S2; 1A1-3B; MIG19; Next to BRCA1 gene 1 protein; Membrane Component,Chromosome 17,Surface Marker 2; Cell migration-inducing gene 19 protein

Neighbor Of BRCA1 Gene 1 (NBR1)
CCC P875
HGNC 6746
MGI 108498
PubMed 20616007
RGD 69195
UniProt Q14596
Wiki NBR1
NBR1 was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. NBR1 targets the ubiquitin-associated p62/SQSTM1 to sarcomeres, and p62 in turn interacts with MURF2, a muscle-specific RING-B-box E3 ligase and ligand of the transactivation domain of the serum response transcription factor (SRF). Nuclear translocation of MURF2 was induced by mechanical inactivity and caused reduction of nuclear SRF and repression of transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neighbor Of BRCA1 Gene 1 (NBR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neighbor Of BRCA1 Gene 1 (NBR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neighbor Of BRCA1 Gene 1 (NBR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neighbor Of BRCA1 Gene 1 (NBR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neighbor Of BRCA1 Gene 1 (NBR1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neighbor Of BRCA1 Gene 1 (NBR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neighbor Of BRCA1 Gene 1 (NBR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neighbor Of BRCA1 Gene 1 (NBR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neighbor Of BRCA1 Gene 1 (NBR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neighbor Of BRCA1 Gene 1 (NBR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neighbor Of BRCA1 Gene 1 (NBR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neighbor Of BRCA1 Gene 1 (NBR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neighbor Of BRCA1 Gene 1 (NBR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neighbor Of BRCA1 Gene 1 (NBR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neighbor Of BRCA1 Gene 1 (NBR1) ELISA Kit Customized Service Offer
  1. "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1."Hum. Mol. Genet. 3:589-594(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes."Gene 262:89-98(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Comparison of the positional cloning methods used to isolate the BRCA1 gene." Hum. Mol. Genet. 4:1259-1266(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins."J. Biol. Chem. 278:34568-34581(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The kinase domain of titin controls muscle gene expression and protein turnover."Science 308:1599-1603(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover."FEBS Lett. 583:1846-1852(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A role for NBR1 in autophagosomal degradation of ubiquitinated substrates."Mol. Cell 33:505-516(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of RSGI RUH-024, a PB1 domain, and of RSGI RUH-046, a UBA domain from human next to BRCA1 gene 1 protein (KIAA0049 protein) R923H variant."Submitted (NOV-2005) to the PDB data bank
  13. "Crystal structure of the PB1 domain of NBR1."FEBS Lett. 580:341-344(2006) [PubMed] [Europe PMC] [Abstract]