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Keratin 81 (KRT81)

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KRTHB1; Hb-1; K81; MLN137; Keratin,Hair,Basic 1; Hard Keratin Type II 1; Keratin, type II cuticular Hb1; Metastatic lymph node 137 gene protein

Keratin 81 (KRT81)
CCC P892
HGNC 6458
MGI 1928858
PubMed 7556444
UniProt Q14533
Wiki KRT81
KRT81 is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The predicted 495-amino acid HB1 protein has an 88-amino acid C-terminal domain. The amino acid sequences of human and sheep HB1 are 90% identical. Northern blot analysis detected HB1 transcripts in human scalp but not unhaired breast epidermis.
HB1 is more closely related to HB3 and HB6 than to HB5. In situ hybridization studies demonstrated that type II keratin genes are sequentially activated in the hair follicle in the following order: HB5--(HB1, HB3)--HB6. Both HB1 and HB3 mRNA syntheses begin 10 to 15 cell layers above the apex of the dermal papilla and end abruptly in the middle of the cortex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP892Hu01 Recombinant Keratin 81 (KRT81) Positive Control; Immunogen; SDS-PAGE; WB.
RPP892Hu04 Recombinant Keratin 81 (KRT81) Positive Control; Immunogen; SDS-PAGE; WB.
RPP892Hu02 Recombinant Keratin 81 (KRT81) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP892Hu01 Polyclonal Antibody to Keratin 81 (KRT81) WB; IHC; ICC; IP.
PAP892Hu04 Polyclonal Antibody to Keratin 81 (KRT81) WB; IHC; ICC; IP.
LAP892Hu71 Biotin-Linked Polyclonal Antibody to Keratin 81 (KRT81) WB; IHC; ICC.
PAP892Hu02 Polyclonal Antibody to Keratin 81 (KRT81) WB; IHC; ICC; IP.
Assay Kits SEP892Hu ELISA Kit for Keratin 81 (KRT81) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Keratin 81 (KRT81) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Keratin 81 (KRT81) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Keratin 81 (KRT81) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Keratin 81 (KRT81) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 81 (KRT81) ELISA Kit Customized Service Offer
  1. "Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle."J. Invest. Dermatol. 110:158-164(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence data and chromosomal localization of human type I and type II hair keratin genes."Exp. Cell Res. 220:357-362(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Sequence and expression of human hair keratin genes."J. Dermatol. Sci. 7:S152-S163(1994) [PubMed] [Europe PMC] [Abstract]
  7. "A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix."Hum. Genet. 101:165-169(1997) [PubMed] [Europe PMC] [Abstract]
  8. "A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1."J. Invest. Dermatol. 111:169-172(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Novel KRT83 and KRT86 mutations associated with monilethrix."Exp. Dermatol. 24:222-224(2015) [PubMed] [Europe PMC] [Abstract]