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Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L)

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KCNE5; AMMECR2; Potassium voltage-gated channel subfamily E regulatory beta subunit 5; AMME syndrome candidate gene 2; Potassium channel subunit beta MiRP4

Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L)
CCC P931
HGNC 6241
MGI 1913490
PubMed 20533308
RGD 1583501
UniProt Q9UJ90
Wiki KCNE1L
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
KCNE1L encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. This intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 Like Protein (KCNE1L) ELISA Kit Customized Service Offer
  1. "KCNE1-like gene is deleted in AMME contiguous gene syndrome: Identification and characterization of the human and mouse homologs."Genomics 60:251-257(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current."Biophys. J. 83:1997-2006(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Alport syndrome and mental retardation: clinical and genetic dissection of the contiguous gene deletion syndrome in Xq22.3 (ATS-MR)."J. Med. Genet. 39:359-365(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation."Am. J. Cardiol. 96:405-407(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation."Heart Rhythm 5:427-435(2008) [PubMed] [Europe PMC] [Abstract]
  7. "KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation."Circ. Arrhythm. Electrophysiol. 4:352-361(2011) [PubMed] [Europe PMC] [Abstract]