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Integral Membrane Protein 1 (ITM1)

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STT3A; TMC; STT3-A; STT3,Subunit Of The Oligosaccharyltransferase Complex Homolog A; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Integral Membrane Protein 1 (ITM1)
CCC P937
HGNC 6172
MGI 105124
RGD 1565793
UniProt P46977
The amino acid sequence of the human B5 was 98.5% identical to that of the mouse protein. A striking feature of the B5 protein was the presence of numerous (10 to 14) potential transmembrane domains, characteristic of an integral membrane protein. Similarity searches in public databases revealed that B5 is 58% similar to the T12A2.2 gene of C. elegans and 60% similar to the STT3 gene of S. cerevisiae.
The predicted 705-amino acid protein has 13 putative transmembrane domains. Northern blot analysis revealed that the gene is expressed in a variety of human tissues, with highest expression in ovary and testis. Northern blot and RT-PCR analysis showed no differences in the level of expression among normal and malignant mesothelial cell lines tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integral Membrane Protein 1 (ITM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integral Membrane Protein 1 (ITM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integral Membrane Protein 1 (ITM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integral Membrane Protein 1 (ITM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integral Membrane Protein 1 (ITM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integral Membrane Protein 1 (ITM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integral Membrane Protein 1 (ITM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integral Membrane Protein 1 (ITM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integral Membrane Protein 1 (ITM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integral Membrane Protein 1 (ITM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integral Membrane Protein 1 (ITM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integral Membrane Protein 1 (ITM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integral Membrane Protein 1 (ITM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integral Membrane Protein 1 (ITM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integral Membrane Protein 1 (ITM1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9."Genomics 31:295-300(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC."Biochim. Biophys. Acta 1306:137-141(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties."Mol. Cell 12:101-111(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits."Biochemistry 44:5982-5992(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms."Cell 136:272-283(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis."J. Biol. Chem. 286:42937-42948(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in STT3A and STT3B cause two congenital disorders of glycosylation."Hum. Mol. Genet. 22:4638-4645(2013) [PubMed] [Europe PMC] [Abstract]