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Speckled 110 kDa (SP110)

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SP110; IIFI41; FI75; SP110 Nuclear Body Protein; Interferon Induced Protein 41, 30kDa; Transcriptional coactivator Sp110; Interferon-induced protein 41/75

Speckled 110 kDa (SP110)
CCC P941
HGNC 5401
MGI 1923364
RGD 1310173
UniProt Q9HB58
SP110 is associated with the PML nuclear body, a macromolecular complex within the nucleus that is deployed to areas of active host or viral DNA replication, transcription, and repair. In addition to the regulation of gene transcription, the PML nuclear body is involved in other cellular processes such as apoptosis, cell cycle control, and the immune response.
The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Speckled 110 kDa (SP110) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Speckled 110 kDa (SP110) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Speckled 110 kDa (SP110) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Speckled 110 kDa (SP110) CLIA Kit Customized Service Offer
n/a ELISA Kit for Speckled 110 kDa (SP110) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Speckled 110 kDa (SP110) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Speckled 110 kDa (SP110) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Speckled 110 kDa (SP110) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Speckled 110 kDa (SP110) CLIA Kit Customized Service Offer
n/a ELISA Kit for Speckled 110 kDa (SP110) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Speckled 110 kDa (SP110) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Speckled 110 kDa (SP110) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Speckled 110 kDa (SP110) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Speckled 110 kDa (SP110) CLIA Kit Customized Service Offer
n/a ELISA Kit for Speckled 110 kDa (SP110) ELISA Kit Customized Service Offer
  1. "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins."J. Biol. Chem. 268:24432-24441(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator."Mol. Cell. Biol. 20:6138-6146(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus."Mol. Cell. Biol. 23:7498-7509(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease."Nat. Genet. 38:620-622(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "No associations of human pulmonary tuberculosis with Sp110 variants."J. Med. Genet. 43:E32-E32(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa."Proc. Natl. Acad. Sci. U.S.A. 103:10364-10368(2006) [PubMed] [Europe PMC] [Abstract]
  14. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]