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HIV1 Tat Specific Factor 1 (HTATSF1)

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TAT-SF1

HIV1 Tat Specific Factor 1 (HTATSF1)
CCC P943
HGNC 5276
MGI 1919709
PubMed 8849451
RGD 1563377
UniProt O43719
Wiki HTATSF1
Sequence analysis predicted that the HTATSF1 protein has 754 amino acids. The N-terminal half of HTATSF1 contains 2 RNA-recognition motifs homologous to those in EWS protein and FUS/TLS, while the C-terminal half is rich in acidic amino acids, particularly glutamate and aspartate, and has several potential serine phosphorylation sites. Northern blot analysis revealed expression of a 3.0-kb HTATSF1 transcript in several cell lines. Immunoblot analysis showed that HTATSF1 is expressed as a 140-kD phosphoprotein in numerous cell types, suggesting that HTATSF1 may mediate a broadly active cellular process in addition to its essential role in Tat activation. Binding analysis showed that HTATSF1 weakly associates with TAR RNA. The association with TAR RNA was substantially enhanced by the presence of Tat.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HIV1 Tat Specific Factor 1 (HTATSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HIV1 Tat Specific Factor 1 (HTATSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HIV1 Tat Specific Factor 1 (HTATSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HIV1 Tat Specific Factor 1 (HTATSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HIV1 Tat Specific Factor 1 (HTATSF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HIV1 Tat Specific Factor 1 (HTATSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HIV1 Tat Specific Factor 1 (HTATSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HIV1 Tat Specific Factor 1 (HTATSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HIV1 Tat Specific Factor 1 (HTATSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HIV1 Tat Specific Factor 1 (HTATSF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HIV1 Tat Specific Factor 1 (HTATSF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HIV1 Tat Specific Factor 1 (HTATSF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HIV1 Tat Specific Factor 1 (HTATSF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HIV1 Tat Specific Factor 1 (HTATSF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HIV1 Tat Specific Factor 1 (HTATSF1) ELISA Kit Customized Service Offer
  1. "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat."Science 274:605-610(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages."EMBO J. 17:3681-3691(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor."Genes Dev. 12:2992-2996(1998) [PubMed] [Europe PMC] [Abstract]
  6. "CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif."Mol. Cell. Biol. 18:5000-5009(1998) [PubMed] [Europe PMC] [Abstract]
  7. "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription."EMBO J. 18:3688-3701(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Tat-SF1 protein associates with RAP30 and human SPT5 proteins."Mol. Cell. Biol. 19:5960-5968(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter."Mol. Cell. Biol. 20:5897-5907(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators."Immunity 14:763-777(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Stimulatory effect of splicing factors on transcriptional elongation."Nature 414:929-933(2001) [PubMed] [Europe PMC] [Abstract]
  12. "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions."Mol. Cell. Biol. 24:9274-9285(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression."AIDS 19:897-905(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  23. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Solution structure of the RRM_1 domain of HIV Tat specific factor 1 variant."Submitted (SEP-2006) to the PDB data bank