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Homeobox Protein D13 (HOXD13)

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HOX4I; SPD

Homeobox Protein D13 (HOXD13)
CCC P948
HGNC 5136
MGI 96205
PubMed 15755899
RGD 1308417
UniProt P35453
Wiki HOXD13
HOXD13 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. HOXD13 gene encodes a polypeptide of 335 amino acids that has high homology to the chicken Hoxd13 gene. They noted that the 5-prime end of the gene encodes 15 alanine residues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeobox Protein D13 (HOXD13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeobox Protein D13 (HOXD13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeobox Protein D13 (HOXD13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeobox Protein D13 (HOXD13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeobox Protein D13 (HOXD13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeobox Protein D13 (HOXD13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeobox Protein D13 (HOXD13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeobox Protein D13 (HOXD13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeobox Protein D13 (HOXD13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeobox Protein D13 (HOXD13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Homeobox Protein D13 (HOXD13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Homeobox Protein D13 (HOXD13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homeobox Protein D13 (HOXD13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homeobox Protein D13 (HOXD13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homeobox Protein D13 (HOXD13) ELISA Kit Customized Service Offer
  1. "Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13."Science 272:548-551(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2."Genomics 10:43-50(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a HOXD13 mutation in a VACTERL patient."Am. J. Med. Genet. A 146:3181-3185(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic structure of HOXD13 gene: a nine polyalanine duplication causes synpolydactyly in two unrelated families."Hum. Mol. Genet. 5:945-952(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Severe digital abnormalities in a patient heterozygous for both a novel missense mutation in HOXD13 and a polyalanine tract expansion in HOXA13."J. Med. Genet. 39:852-856(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Missense mutations in the homeodomain of HOXD13 are associated with brachydactyly types D and E."Am. J. Hum. Genet. 72:984-997(2003) [PubMed] [Europe PMC] [Abstract]
  8. "A 72-year-old Danish puzzle resolved -- comparative analysis of phenotypes in families with different-sized HOXD13 polyalanine expansions."Am. J. Med. Genet. A 138:328-339(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome."Am. J. Hum. Genet. 80:361-371(2007) [PubMed] [Europe PMC] [Abstract]