Homeobox Protein D10 (HOXD10)

HOXD10 is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. However, the HOX4 genes are also coordinately expressed in the CNS and elsewhere in the body mesenchyme. In theory, the effects of a newly derived HOX4 gene could be limited to the limbs by creating a limb-specific promoter.