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HBS1 Like Protein (HBS1L)

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ERFS; HBS1; EF-1a

HBS1 Like Protein (HBS1L)
CCC P977
HGNC 4834
MGI 1891704
PubMed 17592125
RGD 1308509
UniProt Q9Y450
HBS1L encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HBS1 Like Protein (HBS1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HBS1 Like Protein (HBS1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HBS1 Like Protein (HBS1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HBS1 Like Protein (HBS1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for HBS1 Like Protein (HBS1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HBS1 Like Protein (HBS1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HBS1 Like Protein (HBS1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HBS1 Like Protein (HBS1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HBS1 Like Protein (HBS1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for HBS1 Like Protein (HBS1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HBS1 Like Protein (HBS1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HBS1 Like Protein (HBS1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HBS1 Like Protein (HBS1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HBS1 Like Protein (HBS1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for HBS1 Like Protein (HBS1L) ELISA Kit Customized Service Offer
  1. "The product of the mammalian orthologue of the Saccharomyces cerevisiae HBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3-like activity."FEBS Lett. 440:387-392(1998) [PubMed] [Europe PMC] [Abstract]
  2. "An integrated physical and transcript map of human 6q23 encompassing a quantitative trait loci for foetal haemaglobin expression."Thesis (2002), University of Oxford, United Kingdom
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]