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Histone Cluster 1, H2bc (HIST1H2BC)

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HIST1H2BI; HIST1H2BE; HIST1H2BF; HIST1H2BG; H2BFL; H2B/l; H2B.1; H2B Histone Family Member L

Histone Cluster 1, H2bc (HIST1H2BC)
CCC Q002
HGNC 4757
MGI 1915274
PubMed 9119399
RGD 1591796
UniProt P62807
Wiki HIST1H2BC
Histones are basic nuclear proteins that are responsible for the nucleosome structure within the chromosomal fiber in eukaryotes. Albig and Doenecke (1997) found 1 H1 gene (H1.5), 5 H2A genes, 4 H2B genes, 1 H2B pseudogene, 3 H3 genes, 3 H4 genes, and 1 H4 pseudogene. The dinucleotide repeat polymorphic marker D6S105 was localized at the telomeric end of this histone gene cluster. Almost all human histone genes isolated to that time had been localized within the 2 clusters on 6p or in a small group of histone genes on chromosome 1.
By analysis of a YAC contig from chromosome 6p21.3, Albig et al. (1997) characterized a cluster of 35 histone genes, including H2B/l.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bc (HIST1H2BC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bc (HIST1H2BC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bc (HIST1H2BC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bc (HIST1H2BC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bc (HIST1H2BC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bc (HIST1H2BC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bc (HIST1H2BC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bc (HIST1H2BC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bc (HIST1H2BC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bc (HIST1H2BC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2bc (HIST1H2BC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2bc (HIST1H2BC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2bc (HIST1H2BC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2bc (HIST1H2BC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2bc (HIST1H2BC) ELISA Kit Customized Service Offer
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  2. "Human histone gene organization: nonregular arrangement within a large cluster."Genomics 40:314-322(1997) [PubMed] [Europe PMC] [Abstract]
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  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
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  11. "Quantitative proteomic analysis of post-translational modifications of human histones."Mol. Cell. Proteomics 5:1314-1325(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase."Cell 113:507-517(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Inhibition of core histones acetylation by carcinogenic nickel(II)."Mol. Cell. Biochem. 279:133-139(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II."Cell 125:703-717(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Gene-specific characterization of human histone H2B by electron capture dissociation."J. Proteome Res. 5:233-239(2006) [PubMed] [Europe PMC] [Abstract]
  17. "The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."Mol. Cell 43:132-144(2011) [PubMed] [Europe PMC] [Abstract]
  18. "GlcNAcylation of histone H2B facilitates its monoubiquitination."Nature 480:557-560(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."Cell 146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
  20. "USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."Genes Dev. 27:1581-1595(2013) [PubMed] [Europe PMC] [Abstract]