H1 Histone Family, Member 0 (H1F0)

H1F0 is a replacement H1 histone whose transcription is independent of DNA replication. Unlike the transcripts for replication-dependent histones, transcripts for replacement histones, including that for H1F0, are polyadenylated. Marzluff et al. (2002) stated that H1F0 is expressed at high levels during terminal differentiation.

By PCR analysis of chromosomal DNA from a panel of human/rodent somatic cell hybrids, Albig et al. (1993) demonstrated that the H1.0 gene maps to chromosome 22. By fluorescence in situ hybridization, they localized the gene to 22q13.1. Thus, unlike the other H1 genes mapped by Albig et al. (1993), H1.0 lies outside the histone gene cluster on chromosome 6. In contrast, replication-independent histone genes, such as H1F0, lie outside of these clusters.