Perillartine (Per)

Perillartine is a sweetener that is about 2000 times as sweet as sucrose. It is mainly used in Japan. Perillartine is the oxime of perillaldehyde, which is found in Perilla frutescens.

Perillartine were synthesized by the oximation of perillyl aldehyde with hydroxylamine hydrochloric in acid-base buffer solution.Structure of perillartine was characterized by data of infrared spectrum,GC-MS spectrum and 1H NMR spectrum.The effects of pH,reaction temperature and mole ratio of perillyl aldehyde to hydroxylamine hydrochloric on the yield of perillartine were studied.The yield of perillartine was 91.1% with the purity of 98.20%.The yield and purity of perillartine were increased obviously compared to those reported in literatures due to the restraint of the decomposition of perillartine under the optimal conditions.