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Histone Cluster 1, H2ac (HIST1H2AC)

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H2AFL; H2A Histone Family Member L

Histone Cluster 1, H2ac (HIST1H2AC)
CCC Q022
HGNC 4733
MGI 2448287
PubMed 12408966
RGD 1597155
UniProt Q93077
Wiki HIST1H2AC
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
HIST1H2AC is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ022Hu01 Recombinant Histone Cluster 1, H2ac (HIST1H2AC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ022Hu01 Polyclonal Antibody to Histone Cluster 1, H2ac (HIST1H2AC) WB; IHC; ICC; IP.
LAQ022Hu81 FITC-Linked Polyclonal Antibody to Histone Cluster 1, H2ac (HIST1H2AC) WB; IHC; ICC; IF.
LAQ022Hu71 Biotin-Linked Polyclonal Antibody to Histone Cluster 1, H2ac (HIST1H2AC) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2ac (HIST1H2AC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2ac (HIST1H2AC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2ac (HIST1H2AC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2ac (HIST1H2AC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2ac (HIST1H2AC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2ac (HIST1H2AC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2ac (HIST1H2AC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histone Cluster 1, H2ac (HIST1H2AC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histone Cluster 1, H2ac (HIST1H2AC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histone Cluster 1, H2ac (HIST1H2AC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histone Cluster 1, H2ac (HIST1H2AC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histone Cluster 1, H2ac (HIST1H2AC) ELISA Kit Customized Service Offer
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  11. "Precise characterization of human histones in the H2A gene family by top down mass spectrometry."J. Proteome Res. 5:248-253(2006) [PubMed] [Europe PMC] [Abstract]
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  17. "RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling."Cell 150:1182-1195(2012) [PubMed] [Europe PMC] [Abstract]
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  19. "VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription."Mol. Cell 52:459-467(2013) [PubMed] [Europe PMC] [Abstract]
  20. "Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification."Nature 505:564-568(2014) [PubMed] [Europe PMC] [Abstract]
  21. "TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein."Nature 516:116-120(2014) [PubMed] [Europe PMC] [Abstract]