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G1-To-S-Phase Transition Protein 2 (GSPT2)

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eRF3b; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Eukaryotic peptide chain release factor subunit 3b

G1-To-S-Phase Transition Protein 2 (GSPT2)
CCC Q035
HGNC 4622
MGI 1316727
PubMed 10575220
RGD 1563213
UniProt Q8IYD1
Wiki GSPT2
GSPT2 is closely related to GSPT1, a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1, functions as a polypeptide chain release factor.
The deduced 632-amino acid protein has a 2-domain structure with a unique N-terminal region and a conserved C-terminal eukaryotic elongation factor 1-alpha-like domain. Mouse Gspt2 shares 81% identity with human GSPT1. RT-PCR analysis revealed expression in all tissues examined, with relative abundance in brain. In contrast to Gspt1, Gspt2 expression in Swiss 3T3 cells did not fluctuate with the cell cycle or upon phorbol ester stimulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G1-To-S-Phase Transition Protein 2 (GSPT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G1-To-S-Phase Transition Protein 2 (GSPT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G1-To-S-Phase Transition Protein 2 (GSPT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G1-To-S-Phase Transition Protein 2 (GSPT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for G1-To-S-Phase Transition Protein 2 (GSPT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G1-To-S-Phase Transition Protein 2 (GSPT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G1-To-S-Phase Transition Protein 2 (GSPT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G1-To-S-Phase Transition Protein 2 (GSPT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G1-To-S-Phase Transition Protein 2 (GSPT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for G1-To-S-Phase Transition Protein 2 (GSPT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G1-To-S-Phase Transition Protein 2 (GSPT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G1-To-S-Phase Transition Protein 2 (GSPT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G1-To-S-Phase Transition Protein 2 (GSPT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G1-To-S-Phase Transition Protein 2 (GSPT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for G1-To-S-Phase Transition Protein 2 (GSPT2) ELISA Kit Customized Service Offer
  1. "Identification of a novel termination release factor eRF3b expressing the eRF3 activity in vitro and in vivo."Mol. Biol. (Mosk.) 35:672-681(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation."Mol. Cell. Biol. 25:5801-5811(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III."Int. J. Cancer 119:1829-1836(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway."Mol. Cell. Biol. 27:5619-5629(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay."PLoS Biol. 6:E111-E111(2008) [PubMed] [Europe PMC] [Abstract]
  9. "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay."Genes Dev. 23:1091-1105(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]