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X Antigen Family, Member 1A (XAGE1A)

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GAGED2; XAGE1; XAGE1B; XAGE1C; XAGE1D; XAGE1E; CT12.1a; G Antigen Family D 2; Cancer/Testis Antigen Family 12 Member 1a

X Antigen Family, Member 1A (XAGE1A)
CCC Q045
HGNC 4111
PubMed 22515959
UniProt Q9HD64
Brinkmann et al. (1999) identified 3 related genes, which they termed XAGEs, by homology walking using the dbEST database. ESTs of the XAGE group were found in cDNA libraries from testis, Ewing sarcoma , alveolar rhabdomyosarcoma, fetal tissues, and germ cell tumors by database analysis.
XAGE1A is 1 of 5 copies of the XAGE1 gene. The protein shows strong homology with members of the GAGE/PAGE family in the C terminus and has a potential transmembrane domain in the N terminus. Expression analyses revealed high expression in normal testis and low expression in lung and peripheral blood lymphocytes. Expression was also found in 7 of 8 Ewing cell lines, in 4 of 9 Ewing sarcoma patient samples, and in 1 of 1 alveolar rhabdomyosarcoma tumor sample.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant X Antigen Family, Member 1A (XAGE1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to X Antigen Family, Member 1A (XAGE1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to X Antigen Family, Member 1A (XAGE1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for X Antigen Family, Member 1A (XAGE1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for X Antigen Family, Member 1A (XAGE1A) ELISA Kit Customized Service Offer
  1. "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma."Cancer Res. 60:4752-4755(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers."Mol. Cancer Ther. 1:441-450(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors."Cancer Immun. 7:5-5(2007) [PubMed] [Europe PMC] [Abstract]