P Antigen Family, Member 3 (PAGE3)

Many human tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient.Chen et al. (1998) manipulated the androgen-sensitive, nontumorigenic, prostate-specific antigen (PSA)-secreting cell line LNCaP in vivo to produce 3 cell sublines that were progressively more tumorigenic, metastatic, and androgen-insensitive. To screen for genes associated with cancer progression, Chen et al. (1998) performed differential display PCR using these sublines and isolated 2 members of the GAGE family, GAGEB1 and GAGE7.

By searching an EST database for sequences similar to PAGE1, Brinkmann et al. (1998) identified PAGE3. Hartz (2008) mapped the PAGE3 gene to chromosome Xp11.21 based on an alignment of the PAGE3 sequence with the genomic sequence.