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G Antigen 5 (GAGE5)

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CT4.5; Cancer/Testis Antigen Family 4 Member 5

G Antigen 5 (GAGE5)
CCC Q052
HGNC 4102
UniProt Q13069
Human melanoma cells express several distinct antigens that are recognized by autologous cytolytic T lymphocytes (CTLs). One class of these antigens is encoded by genes, such as MAGE1 (MAGEA1), MAGE3 (MAGEA3), and BAGE, that are expressed in a large fraction of tumors of various histologic types but are silent in normal adult tissues, except for testis. GAGE1 as a gene encoding an antigen that is present on melanoma MZ2-MEL cells and is recognized by autologous CTLs. The GAGE2 to -6 cDNAs differ mainly by single nucleotide substitutions that are scattered throughout the sequence.
The deduced GAGE5 protein has 117 amino acids. RT-PCR using primers common to GAGE1 to -6 found expression of these genes in various tumors but no expression in any normal adult tissue tested except testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Antigen 5 (GAGE5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Antigen 5 (GAGE5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Antigen 5 (GAGE5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Antigen 5 (GAGE5) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Antigen 5 (GAGE5) ELISA Kit Customized Service Offer
  1. "A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma."J. Exp. Med. 182:689-698(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
  4. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]