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Cytochrome P450 2C8 (CYP2C8)

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CPC8; Cytochrome P450,Subfamily IIC(Mephenytoin 4-Hydroxylase)Polypeptide 8; S-mephenytoin 4-hydroxylase

Cytochrome P450 2C8 (CYP2C8)
CCC Q091
HGNC 2622
MGI 1917138
PubMed 21289076
UniProt P10632
Wiki CYP2C8
CYP2C8 is one of the major drug-metabolizing CYP450 isoforms. The induction of CYP2C8 in native porcine coronary artery endothelial cells by beta-naphthoflavone enhances the formation of 11,12-epoxyeicosatrienoic acid, as well as endothelium-derived hyperpolarizing factor-mediated hyperpolarization and relaxation. Transfection of coronary arteries with CYP2C8 antisense oligonucleotides resulted in decreased levels of CYP2C and attenuated the endothelium-derived hyperpolarizing factor-mediated vascular responses. Thus, a CYP-epoxygenase product is an essential component of the endothelium-derived hyperpolarizing factor-mediated relaxation in the porcine coronary artery, and CYP2C8 fulfills the criteria for the coronary endothelium-derived hyperpolarization factor synthase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 2C8 (CYP2C8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 2C8 (CYP2C8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 2C8 (CYP2C8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 2C8 (CYP2C8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 2C8 (CYP2C8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 2C8 (CYP2C8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 2C8 (CYP2C8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 2C8 (CYP2C8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 2C8 (CYP2C8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 2C8 (CYP2C8) ELISA Kit Customized Service Offer
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  9. "Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase."Biochemistry 27:6929-6940(1988) [PubMed] [Europe PMC] [Abstract]
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  11. "Sequence of a human liver cytochrome P-450 cDNA clone."Nucleic Acids Res. 18:5550-5550(1990) [PubMed] [Europe PMC] [Abstract]
  12. "A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin."J. Hum. Genet. 49:582-585(2004) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site."J. Biol. Chem. 279:9497-9503(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid."J. Biol. Chem. 283:17227-17237(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid."Pharmacogenetics 11:597-607(2001) [PubMed] [Europe PMC] [Abstract]
  17. "CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes."Biochem. Pharmacol. 64:1579-1589(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]