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Casein Kinase 1 Gamma 2 (CSNK1g2)

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CK1g2; Casein kinase I isoform gamma-2

Casein Kinase 1 Gamma 2 (CSNK1g2)
CCC Q100
HGNC 2455
MGI 1920014
RGD 621407
UniProt P78368
The casein kinase I (CKI) gene family encodes serine/threonine kinases that preferentially phosphorylate acidic substrates using ATP as a phosphate donor. CKI proteins are monomeric and range from 25 to 55 kD.
Kitabayashi et al. (1997) isolated a clone of immature cDNA encoding human casein kinase I gamma-2 (CSNK1G2) by screening a human testis cDNA library with a PCR-amplified probe representing the kinase domain of rat casein kinase I gamma-2. The predicted amino acid sequence consists of 416 residues, 94% of which are identical to those of the rat homolog.Kitabayashi et al. (1997) mapped the human CSNK1G2 gene to 19p13.3 by fluorescence in situ hybridization and PCR analysis of a human/rodent hybrid cell panel.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 1 Gamma 2 (CSNK1g2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 1 Gamma 2 (CSNK1g2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 1 Gamma 2 (CSNK1g2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 1 Gamma 2 (CSNK1g2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 1 Gamma 2 (CSNK1g2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 1 Gamma 2 (CSNK1g2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 1 Gamma 2 (CSNK1g2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 1 Gamma 2 (CSNK1g2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 1 Gamma 2 (CSNK1g2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 1 Gamma 2 (CSNK1g2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 1 Gamma 2 (CSNK1g2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 1 Gamma 2 (CSNK1g2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 1 Gamma 2 (CSNK1g2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 1 Gamma 2 (CSNK1g2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 1 Gamma 2 (CSNK1g2) ELISA Kit Customized Service Offer
  1. "Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2)."Genomics 46:133-137(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population."Neurosci. Lett. 368:2-6(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase."Oncogene 23:4422-4429(2004) [PubMed] [Europe PMC] [Abstract]
  7. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."J. Biol. Chem. 280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling."Oncogene 27:7235-7247(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin."Mol. Biol. Cell 20:348-357(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The structure of casein kinase 1 gamma 2."Submitted (JUL-2011) to the PDB data bank
  14. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]