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Cytochrome C Oxidase Assembly Protein 17 (COX17)

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Cytochrome c oxidase copper chaperone

Cytochrome C Oxidase Assembly Protein 17 (COX17)
CCC Q109
HGNC 2264
MGI 1333806
PubMed 17208454
RGD 620548
UniProt Q14061
Wiki COX17
This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme.
COX17 shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Assembly Protein 17 (COX17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Assembly Protein 17 (COX17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Assembly Protein 17 (COX17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome C Oxidase Assembly Protein 17 (COX17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome C Oxidase Assembly Protein 17 (COX17) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Assembly Protein 17 (COX17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Assembly Protein 17 (COX17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Assembly Protein 17 (COX17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome C Oxidase Assembly Protein 17 (COX17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome C Oxidase Assembly Protein 17 (COX17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Assembly Protein 17 (COX17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Assembly Protein 17 (COX17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Assembly Protein 17 (COX17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome C Oxidase Assembly Protein 17 (COX17) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome C Oxidase Assembly Protein 17 (COX17) ELISA Kit Customized Service Offer
  1. "Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment."Hum. Genet. 99:329-333(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and localization of human COX17, a gene involved in mitochondrial copper transport."Hum. Genet. 107:69-74(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase."Genome Biol. 13:RESEARCH0012.1-RESEARCH0012.14(2012) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "A structural-dynamical characterization of human Cox17."J. Biol. Chem. 283:7912-7920(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import."Proc. Natl. Acad. Sci. U.S.A. 107:20190-20195(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective."J. Biol. Chem. 286:34382-34390(2011) [PubMed] [Europe PMC] [Abstract]