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Cytochrome C Oxidase Assembly Protein 15 (COX15)

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Cytochrome C Oxidase Assembly Protein 15 (COX15)
CCC Q110
HGNC 2263
MGI 1920112
PubMed 9878253
RGD 1312043
UniProt Q7KZN9
Wiki COX15
COX15 is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region.
The amino acid sequences of both isoforms are 42% identical to that of yeast cox15. Sequence analysis indicated that COX15 contains a mitochondrial leader peptide and 5 transmembrane domains. Using in vitro mitochondrial import and trypsin-protection assays, the authors demonstrated that the COX15 protein is targeted to mitochondria. Northern blot analysis revealed that COX15 is expressed as 1.5-, 1.8-, and 3-kb mRNAs predominantly in tissues characterized by high rates of oxidative phosphorylation (OXPHOS), including muscle, heart, and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Assembly Protein 15 (COX15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Assembly Protein 15 (COX15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Assembly Protein 15 (COX15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome C Oxidase Assembly Protein 15 (COX15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome C Oxidase Assembly Protein 15 (COX15) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Assembly Protein 15 (COX15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Assembly Protein 15 (COX15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Assembly Protein 15 (COX15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome C Oxidase Assembly Protein 15 (COX15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome C Oxidase Assembly Protein 15 (COX15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome C Oxidase Assembly Protein 15 (COX15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome C Oxidase Assembly Protein 15 (COX15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome C Oxidase Assembly Protein 15 (COX15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome C Oxidase Assembly Protein 15 (COX15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome C Oxidase Assembly Protein 15 (COX15) ELISA Kit Customized Service Offer
  1. "Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain."Genomics 54:494-504(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy."Am. J. Hum. Genet. 72:101-114(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome."J. Med. Genet. 41:540-544(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Novel mutations in COX15 in a long surviving Leigh syndrome patient with cytochrome c oxidase deficiency."J. Med. Genet. 42:E28-E28(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Infantile cardioencephalopathy due to a COX15 gene defect: report and review."Am. J. Med. Genet. A 155:840-844(2011) [PubMed] [Europe PMC] [Abstract]