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Chromodomain Protein, Y Like Protein (CDYL)

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CDYL1; CDY-Like,Autosomal; Testis-Specific Chromodomain Y-Like Protein

Chromodomain Protein, Y Like Protein (CDYL)
CCC Q121
HGNC 1811
MGI 1339956
PubMed 22009739
RGD 1549745
UniProt Q9Y232
CDYL bridged the interaction between REST and G9A/EHMT1 in vitro and in vivo and functioned as a REST corepressor that facilitated G9A recruitment to REST target genes. Knockdown of CDYL and G9A in immortalized human mammary epithelial cells led to oncogenic transformation in vitro. REST/CDYL/G9A directly repressed transcription of TRKC (NTRK3), whose overexpression was sufficient to cause cellular transformation. Knockdown of CDYL also augmented cellular transformation in a human cell culture model of cervical cancer.Human CDYL shares 93% and 63% protein sequence identity with mouse Cdyl and human CDY, respectively. Northern blot analysis revealed that human CDYL was expressed at moderate levels in all tissues examined, indicating that it may perform a housekeeping function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Protein, Y Like Protein (CDYL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Protein, Y Like Protein (CDYL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Protein, Y Like Protein (CDYL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Protein, Y Like Protein (CDYL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Protein, Y Like Protein (CDYL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Protein, Y Like Protein (CDYL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Protein, Y Like Protein (CDYL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Protein, Y Like Protein (CDYL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Protein, Y Like Protein (CDYL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Protein, Y Like Protein (CDYL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Protein, Y Like Protein (CDYL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Protein, Y Like Protein (CDYL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Protein, Y Like Protein (CDYL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Protein, Y Like Protein (CDYL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Protein, Y Like Protein (CDYL) ELISA Kit Customized Service Offer
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  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation."Mol. Cell 32:718-726(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Protein lysine methyltransferase G9a acts on non-histone targets."Nat. Chem. Biol. 4:344-346(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association."J. Biol. Chem. 284:35049-35059(2009) [PubMed] [Europe PMC] [Abstract]
  14. ErratumJ. Biol. Chem. 285:11754-11754(2010)
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27."J. Biol. Chem. 286:42414-42425(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structures of human CDY proteins reveal a crotonase-like fold."Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Solution structure of RSGI RUH-064, a chromo domain from human cDNA."Submitted (OCT-2006) to the PDB data bank