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Cluster Of Differentiation 1c (CD1c)

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CD1C Antigen C Polypeptide; T-cell surface glycoprotein CD1c

Cluster Of Differentiation 1c (CD1c)
CCC Q128
HGNC 1636
PubMed 21167756
UniProt P29017
CD1c encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands.
The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ128Hu01 Recombinant Cluster Of Differentiation 1c (CD1c) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 1c (CD1c) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 1c (CD1c) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 1c (CD1c) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 1c (CD1c) ELISA Kit Customized Service Offer
  1. "Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c."Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts."J. Immunol. 143:1723-1730(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Polymorphism of human CD1 genes."Tissue Antigens 54:122-127(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
  7. "Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens."J. Exp. Med. 192:281-288(2000) [PubMed] [Europe PMC] [Abstract]
  8. "CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection."Nature 404:884-888(2000) [PubMed] [Europe PMC] [Abstract]
  9. "CD1c molecules broadly survey the endocytic system."Proc. Natl. Acad. Sci. U.S.A. 97:8445-8450(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  11. "The 2.5 a structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation."Immunity 33:853-862(2010) [PubMed] [Europe PMC] [Abstract]