Ferric Chelate Reductase 1 Like Protein (FRRS1L)
[Edit]C9orf4; CG6; Brain Protein CG-6; DOMON domain-containing protein FRRS1L
Using positional cloning and exon trapping with cosmid clones in brain cDNA libraries to search for candidate genes for familial dysautonomia (DYS), Chadwick et al. (2000) isolated a C9ORF4 cDNA, which they named CG6. They used PCR to obtain the complete sequence of C9ORF4, which encodes a deduced 344-amino acid transmembrane protein predicted to contain 5 phosphorylation sites. Northern blot analysis revealed high expression of an 8.5-kb transcript in all regions of adult and fetal brain, with weaker expression in medulla and spinal cord and in adult ovary. By somatic cell hybridization analysis, Chadwick et al. (2000) mapped the C9ORF4 gene to chromosome 9. By analysis of cosmid clones and BACs, they localized the gene to the DYS region, 9q31-q33. Chadwick et al. (2000) examined DYS patients and controls and found no mutations in the C9ORF4 gene.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Ferric Chelate Reductase 1 Like Protein (FRRS1L) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Ferric Chelate Reductase 1 Like Protein (FRRS1L) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Ferric Chelate Reductase 1 Like Protein (FRRS1L) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Ferric Chelate Reductase 1 Like Protein (FRRS1L) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Ferric Chelate Reductase 1 Like Protein (FRRS1L) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Ferric Chelate Reductase 1 Like Protein (FRRS1L) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Ferric Chelate Reductase 1 Like Protein (FRRS1L) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Ferric Chelate Reductase 1 Like Protein (FRRS1L) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Ferric Chelate Reductase 1 Like Protein (FRRS1L) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Ferric Chelate Reductase 1 Like Protein (FRRS1L) | ELISA Kit Customized Service Offer |
- "Cloning, mapping, and expression of a novel brain-specific transcript in the familial dysautonomia candidate region on chromosome 9q31."Mamm. Genome 11:81-83(2000) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]