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Beta-1,4-Galactosyltransferase 6 (b4GALT6)

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Beta4GalT-VI; Glucosylceramide beta-1,4-galactosyltransferase; Lactosylceramide synthase; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6

Beta-1,4-Galactosyltransferase 6 (b4GALT6)
CCC Q171
HGNC 929
MGI 1928380
PubMed 21518140
RGD 71046
UniProt Q9UBX8
The enzyme galactosyltransferase catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine. In addition to a biosynthetic role, galactosyltransferases may be components of plasma membranes where they may function in intercellular recognition and/or adhesion.
Lo et al. (1998) cloned 5 homologs of B4GALT1, including B4GALT6. The B4GALT6 cDNA encodes a 382-amino acid polypeptide containing a single transmembrane domain, a catalytic domain, and potential glycosylation sites. B4GALT6 is most closely related to B4GALT5, sharing 68% amino acid identity. Northern blot analysis revealed that B4GALT6 is expressed as a 7.0-kb mRNA in several human tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,4-Galactosyltransferase 6 (b4GALT6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,4-Galactosyltransferase 6 (b4GALT6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,4-Galactosyltransferase 6 (b4GALT6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,4-Galactosyltransferase 6 (b4GALT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,4-Galactosyltransferase 6 (b4GALT6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,4-Galactosyltransferase 6 (b4GALT6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,4-Galactosyltransferase 6 (b4GALT6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,4-Galactosyltransferase 6 (b4GALT6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,4-Galactosyltransferase 6 (b4GALT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,4-Galactosyltransferase 6 (b4GALT6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,4-Galactosyltransferase 6 (b4GALT6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,4-Galactosyltransferase 6 (b4GALT6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,4-Galactosyltransferase 6 (b4GALT6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,4-Galactosyltransferase 6 (b4GALT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,4-Galactosyltransferase 6 (b4GALT6) ELISA Kit Customized Service Offer
  1. "The expanding beta 4-galactosyltransferase gene family: messages from the databanks."Glycobiology 8:517-526(1998) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and expression of human lactosylceramide synthase."Biochim. Biophys. Acta 1438:301-304(1999) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "UDPgalactose:glucosylceramide beta 1->4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes."Biochim. Biophys. Acta 923:136-142(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney."J. Biol. Chem. 267:7148-7153(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions."Biochim. Biophys. Acta 1473:35-53(1999) [PubMed] [Europe PMC] [Abstract]