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Aldehyde Oxidase 1 (AOX1)

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AO; AOH1; Azaheterocycle hydroxylase

Aldehyde Oxidase 1 (AOX1)
CCC Q195
HGNC 553
MGI 88035
PubMed 19040632
RGD 620528
UniProt Q06278
Wiki AOX1
Aldehyde oxidase (AO) produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. The human protein was 49% identical to rat XDH and contained several characteristic XDH signature sequences. AOX1 was expressed as a 5.1-kb mRNA predominantly in liver. A 4.5-kb transcript observed in heart, brain, and kidney arose by use of an alternative polyadenylation site.Analysis of a YAC contig revealed that the AOX1 gene is within 280 kb of the D2S116 marker, which is inseparable by recombination from the ALS2 locus. AOX1 is expressed in the ventral horn of the spinal cord, primarily in the glial cells. Based on the tissue localization, linkage data, and the biochemical role of AOX1 in the free radical pathway, these authors suggested that AOX1 is a candidate gene for ALS2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldehyde Oxidase 1 (AOX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldehyde Oxidase 1 (AOX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldehyde Oxidase 1 (AOX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldehyde Oxidase 1 (AOX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldehyde Oxidase 1 (AOX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldehyde Oxidase 1 (AOX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldehyde Oxidase 1 (AOX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldehyde Oxidase 1 (AOX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldehyde Oxidase 1 (AOX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldehyde Oxidase 1 (AOX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldehyde Oxidase 1 (AOX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldehyde Oxidase 1 (AOX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldehyde Oxidase 1 (AOX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldehyde Oxidase 1 (AOX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldehyde Oxidase 1 (AOX1) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ195Bo01 Recombinant Aldehyde Oxidase 1 (AOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ195Bo21 Monoclonal Antibody to Aldehyde Oxidase 1 (AOX1) WB; IHC; ICC; IP.
PAQ195Bo01 Polyclonal Antibody to Aldehyde Oxidase 1 (AOX1) WB; IHC; ICC; IP.
Assay Kits SEQ195Bo ELISA Kit for Aldehyde Oxidase 1 (AOX1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase."Proc. Natl. Acad. Sci. U.S.A. 90:10690-10694(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, refined chromosomal mapping, and structural analysis of the human gene encoding aldehyde oxidase (AOX1), a candidate for the ALS2 gene."Redox Rep. 3:135-144(1997)
  3. "Mutation of human molybdenum cofactor sulfurase gene is responsible to classical xanthinuria type II."Biochem. Biophys. Res. Commun. 282:1194-1200(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon."Arch. Biochem. Biophys. 319:481-490(1995) [PubMed] [Europe PMC] [Abstract]
  7. "In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver."Drug Metab. Dispos. 25:805-813(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is down-regulated by adiponectin and fenofibric acid in hepatocytes in vitro."Biochem. Biophys. Res. Commun. 350:731-735(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Mammalian aldehyde oxidases: genetics, evolution and biochemistry."Cell. Mol. Life Sci. 65:1019-1048(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release."FEBS Lett. 582:2965-2972(2008) [PubMed] [Europe PMC] [Abstract]
  11. "In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase."Drug Metab. Dispos. 38:1322-1327(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes."Drug Metab. Dispos. 40:267-275(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance."Drug Metab. Dispos. 40:1441-1448(2012) [PubMed] [Europe PMC] [Abstract]
  14. "The role of aldehyde oxidase in drug metabolism."Expert Opin. Drug Metab. Toxicol. 8:487-503(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase."Drug Metab. Dispos. 41:24-29(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship."Drug Metab. Dispos. 41:1797-1804(2013) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "The impact of single nucleotide polymorphisms on human aldehyde oxidase."Drug Metab. Dispos. 40:856-864(2012) [PubMed] [Europe PMC] [Abstract]