Dihydrodiol Dehydrogenase 2 (DDH2)

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AKR1C2; DD; BABP; DD2; HAKRD; MCDR2; Aldo-Keto Reductase Family 1,Member C2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase Type III

Dihydrodiol Dehydrogenase 2 (DDH2)
Dihydrodiol dehydrogenase (DD; EC 1.3.1.20), a member of the aldo-oxo reductase (AKR) superfamily, catalyzes the NADP-linked oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols. DDH2 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ200Hu01 Recombinant Dihydrodiol Dehydrogenase 2 (DDH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ200Hu01 Polyclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) WB; IHC; ICC; IP.
MAQ200Hu21 Monoclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) WB; IHC; ICC; IP.
Assay Kits SEQ200Hu ELISA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dihydrodiol Dehydrogenase 2 (DDH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dihydrodiol Dehydrogenase 2 (DDH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dihydrodiol Dehydrogenase 2 (DDH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dihydrodiol Dehydrogenase 2 (DDH2) ELISA Kit Customized Service Offer
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  12. "Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation."Am. J. Hum. Genet. 89:201-218(2011) [PubMed] [Europe PMC] [Abstract]
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  16. "Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme."J. Mol. Biol. 364:747-763(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding."J. Mol. Biol. 369:525-540(2007) [PubMed] [Europe PMC] [Abstract]