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A Disintegrin And Metalloprotease 20 (ADAM20)

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Disintegrin and metalloproteinase domain-containing protein 20

A Disintegrin And Metalloprotease 20 (ADAM20)
CCC Q207
HGNC 199
UniProt O43506
ADAM20 and/or ADAM21 is the functional equivalent of sperm fertilin-alpha, since that gene is nonfunctional in human.Sequence analysis of the cDNAs indicated that the 5-prime untranslated region of the ADAM20 mRNA is alternatively spliced.
The predicted 726-amino acid ADAM20 protein contains a consensus zinc-binding site of metalloproteases, and both ADAM20 and ADAM21 have putative cell-fusion peptides required for sperm-egg fusion. Overall, the 2 proteins are 50% identical and share sequence similarity with ADAM9 and the fertilins. The exclusive expression of ADAM20 and ADAM21 in human testis and their sequence similarity with the fertilins suggested that they too are expressed on sperm cells and are involved in sperm maturation and/or fertilization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ207Hu01 Recombinant A Disintegrin And Metalloprotease 20 (ADAM20) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ207Hu01 Polyclonal Antibody to A Disintegrin And Metalloprotease 20 (ADAM20) WB; IHC; ICC; IP.
LAQ207Hu81 FITC-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 20 (ADAM20) WB; IHC; ICC; IF.
LAQ207Hu71 Biotin-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 20 (ADAM20) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 20 (ADAM20) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 20 (ADAM20) ELISA Kit Customized Service Offer
  1. "ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha."Gene 206:273-282(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries."Gene 237:61-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]