C-Type Lectin Domain Family 3, Member A (CLEC3A)
[Edit]CLECSF1; Cartilage-derived C-type lectin; C-Type(Calcium Dependent,Carbohydrate-Recognition Domain)Lectin,Superfamily Member 1(Cartilage-Derived)
CLEC3A has a signal peptide, an N-terminal domain of coiled-coil alpha helices predicted to mediate trimer formation, residues involved in calcium chelation, and 6 conserved cysteines. Northern blot analysis detected a CLEC3A transcript of about 2 kb only in human fetal, calf, and adult bovine articular cartilage and in cultured fetal and calf chondrocytes. In fetal rib growth plate, highest expression was detected in the upper hypertrophic and proliferating zones.CLEC3A was expressed in normal human breast, but not in any other normal human tissue examined. CLEC3A was expressed in breast cancer tissue, all breast cancer cell lines examined, and some colon cancer cell lines. Western blot analysis of transfected human cell lines showed a 20-kD CLEC3A protein in lysed cells, the culture medium, and extracellular matrix.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant C-Type Lectin Domain Family 3, Member A (CLEC3A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to C-Type Lectin Domain Family 3, Member A (CLEC3A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to C-Type Lectin Domain Family 3, Member A (CLEC3A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for C-Type Lectin Domain Family 3, Member A (CLEC3A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for C-Type Lectin Domain Family 3, Member A (CLEC3A) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant C-Type Lectin Domain Family 3, Member A (CLEC3A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to C-Type Lectin Domain Family 3, Member A (CLEC3A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to C-Type Lectin Domain Family 3, Member A (CLEC3A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for C-Type Lectin Domain Family 3, Member A (CLEC3A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for C-Type Lectin Domain Family 3, Member A (CLEC3A) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant C-Type Lectin Domain Family 3, Member A (CLEC3A) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to C-Type Lectin Domain Family 3, Member A (CLEC3A) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to C-Type Lectin Domain Family 3, Member A (CLEC3A) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for C-Type Lectin Domain Family 3, Member A (CLEC3A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for C-Type Lectin Domain Family 3, Member A (CLEC3A) | ELISA Kit Customized Service Offer |
- "The cartilage-derived, C-type lectin (CLECSF1): structure of the gene and chromosomal location."Biochim. Biophys. Acta 1446:193-202(1999) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity."J. Cell. Biochem. 106:693-702(2009) [PubMed] [Europe PMC] [Abstract]