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Melanoma Antigen Family A3 (MAGEA3)

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MAGE3; HYPD; HIP8; CT1.3; Melanoma-Associated Antigen 3; Antigen MZ2-D; MAGE-3 Antigen; Cancer/Testis Antigen Family 1, Member 3

Melanoma Antigen Family A3 (MAGEA3)
CCC Q282
HGNC 6801
PubMed 16331618
UniProt P43357
Wiki MAGEA3
MAGEA3 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. MAGE3 cDNA was cloned from a melanoma cell cDNA library. The gene encodes a 314-amino acid polypeptide. RT-PCR revealed that MAGE2 is expressed in a variety of cancer cell lines, but among normal tissues only in testis and placenta.MAGEA3 gene comprises 3 exons, with the last exon containing the entire coding sequence.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ282Hu01 Recombinant Melanoma Antigen Family A3 (MAGEA3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Melanoma Antigen Family A3 (MAGEA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanoma Antigen Family A3 (MAGEA3) Polyclonal Antibody Customized Service Offer
Assay Kits SEQ282Hu ELISA Kit for Melanoma Antigen Family A3 (MAGEA3) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Human class I histocompatibility antigen (HLA-A complex with a nonameric peptide from melanoma-associated antigen 3 (residues 271-279)."Submitted (FEB-2009) to the PDB data bank