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Melanoma Antigen Family B4 (MAGEB4)

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CT3.6; Cancer/Testis Antigen Family 3, Member 6

Melanoma Antigen Family B4 (MAGEB4)
CCC Q291
HGNC 6811
PubMed 10706124
UniProt O15481
MAGEB4 is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis.
Lurquin et al. (1997) identified the MAGEB4 gene within a cluster of 4 MAGE-related genes in Xp21.3. See MAGEB1. RT-PCR analysis found that MAGEB4 is expressed in testis. The deduced MAGEB3 protein has 346 amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Melanoma Antigen Family B4 (MAGEB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Melanoma Antigen Family B4 (MAGEB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Melanoma Antigen Family B4 (MAGEB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Melanoma Antigen Family B4 (MAGEB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Melanoma Antigen Family B4 (MAGEB4) ELISA Kit Customized Service Offer
  1. "Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins."Genomics 46:397-408(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]