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SH3 Domain Binding Protein 1 (SH3BP1)

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ARHGAP43

SH3 Domain Binding Protein 1 (SH3BP1)
CCC Q337
HGNC 10824
MGI 104603
PubMed 21658605
RGD 1306275
UniProt Q9Y3L3
Wiki SH3BP1
SH3BP1 Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. 2 isoforms of the human protein are produced by alternative splicing. The importance of the SH3 domain of Hck in kinase regulation, substrate phosphorylation, and ligand binding has been established. Two major interacting proteins were the actin binding proteins Wiskott-Aldrich syndrome protein (WASP) and WASP-interacting protein (WIP). In mammalian cells, ELMO1 interacts with Dock180 as a component of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Binding Protein 1 (SH3BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Binding Protein 1 (SH3BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Binding Protein 1 (SH3BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Binding Protein 1 (SH3BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Binding Protein 1 (SH3BP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Binding Protein 1 (SH3BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Binding Protein 1 (SH3BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Binding Protein 1 (SH3BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Binding Protein 1 (SH3BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Binding Protein 1 (SH3BP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Binding Protein 1 (SH3BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Binding Protein 1 (SH3BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Binding Protein 1 (SH3BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Binding Protein 1 (SH3BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Binding Protein 1 (SH3BP1) ELISA Kit Customized Service Offer
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