≡

Ubiquitination Factor E4B (UBE4B)

[Edit]

UBOX3; E4; UFD2; HDNB1; Homozygously deleted in neuroblastoma 1; Ubiquitin fusion degradation protein 2

Ubiquitination Factor E4B (UBE4B)
CCC Q355
HGNC 12500
MGI 1927086
PubMed 21317885
RGD 1304738
UniProt O95155
Wiki UBE4B
UBE4Bencodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UBE4B has a C-terminal U-box domain including a proline residue perfectly conserved among U-box proteins. The deduced 903-amino acid protein shares weak similarity with Dictyostelium NOSA, a developmental regulator involved in proteasomal degradation of ubiquitinated proteins. Ufd2a interacted with Vcp, a AAA-family ATPase implicated in protein folding. the mouse Ube4b gene contains 27 coding exons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitination Factor E4B (UBE4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitination Factor E4B (UBE4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitination Factor E4B (UBE4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitination Factor E4B (UBE4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitination Factor E4B (UBE4B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitination Factor E4B (UBE4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitination Factor E4B (UBE4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitination Factor E4B (UBE4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitination Factor E4B (UBE4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitination Factor E4B (UBE4B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitination Factor E4B (UBE4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitination Factor E4B (UBE4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitination Factor E4B (UBE4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitination Factor E4B (UBE4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitination Factor E4B (UBE4B) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression analysis of five novel genes in chromosome 1p36."Genomics 50:187-198(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line." Oncogene 19:4302-4307(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis."Biochem. J. 361:587-595(2002) [PubMed] [Europe PMC] [Abstract]
  4. "A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells."PLoS ONE 6:E28861-E28861(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]