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Actin Related Protein 8 (ACTR8)

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ARP8; INO80N; INO80 Complex Subunit N

Actin Related Protein 8 (ACTR8)
CCC Q437
HGNC 14672
MGI 1860775
PubMed 21947284
RGD 1311878
UniProt Q9H981
Human Arp8 (hArp8), an ortholog of yeast nuclear Arp8, was recently found to be associated with the hINO80-chromatin remodeling complex along with hArp5.This is the first example where a member of the actin family is found to be associated with mitotic chromosomes. Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior. In contrast, depletion of hIno80 and hArp5 did not cause misalignment of chromosomes, suggesting that the role of hArp8 at mitotic chromosomes is independent of the activity of hINO80 complexes. These findings provide the first insight into a novel function of actin family members in mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Related Protein 8 (ACTR8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Related Protein 8 (ACTR8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Related Protein 8 (ACTR8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Related Protein 8 (ACTR8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 8 (ACTR8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Related Protein 8 (ACTR8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Related Protein 8 (ACTR8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Related Protein 8 (ACTR8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Related Protein 8 (ACTR8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 8 (ACTR8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Related Protein 8 (ACTR8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Related Protein 8 (ACTR8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Related Protein 8 (ACTR8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Related Protein 8 (ACTR8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 8 (ACTR8) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex."J. Biol. Chem. 280:41207-41212(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment."Exp. Cell Res. 314:859-868(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of Actin-related protein 8 and its contribution to nucleosome binding."Nucleic Acids Res. 40:11036-11046(2012) [PubMed] [Europe PMC] [Abstract]