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Polyhomeotic Like Protein 3 (PHC3)

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EDR3; HPH3; PH3; Early Development Regulator 3; Homolog of polyhomeotic 3

Polyhomeotic Like Protein 3 (PHC3)
CCC Q467
HGNC 15682
MGI 2181434
PubMed 12167701
RGD 1307998
UniProt Q8NDX5
Wiki PHC3
Phc3 have essentially the same genomic organisation, with 15 exons specifying proteins of 983 (PHC3) or 981 (Phc3) amino acids, with an overall sequence identity of 93%. The availability of full-length coding sequences for PHC2, PHC3 and Phc3 completes the profile of human and mouse polyhomeotic homologues and has enabled comprehensive comparative analyses of the human, mouse and Drosophilapolyhomeotic proteins. The data indicate that the novel PHC3 and Phc3 proteins are significantly more closely related to PHC2/Phc2 than either is to PHC1/Phc1 and reveal two hitherto unknown but highly conserved N-terminal domains that are shared by the PHC2/Phc2 and PHC3/Phc3 proteins but that are poorly conserved or absent in other polyhomeotic family members.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polyhomeotic Like Protein 3 (PHC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polyhomeotic Like Protein 3 (PHC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polyhomeotic Like Protein 3 (PHC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polyhomeotic Like Protein 3 (PHC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polyhomeotic Like Protein 3 (PHC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polyhomeotic Like Protein 3 (PHC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polyhomeotic Like Protein 3 (PHC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polyhomeotic Like Protein 3 (PHC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polyhomeotic Like Protein 3 (PHC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polyhomeotic Like Protein 3 (PHC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polyhomeotic Like Protein 3 (PHC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polyhomeotic Like Protein 3 (PHC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polyhomeotic Like Protein 3 (PHC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polyhomeotic Like Protein 3 (PHC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polyhomeotic Like Protein 3 (PHC3) ELISA Kit Customized Service Offer
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  2. "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
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  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."PLoS ONE 4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]