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RNA Polymerase III, DNA Directed Polypeptide F (POLR3F)

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RPC39; RPC6; RNA Polymerase III C39 Subunit; DNA-directed RNA polymerase III subunit RPC6

RNA Polymerase III, DNA Directed Polypeptide F (POLR3F)
CCC Q473
HGNC 15763
MGI 1924086
PubMed 9171375
RGD 1306428
UniProt Q9H1D9
Wiki POLR3F
POLR3F is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase.
hRPC39 interacts physically with both hTBP and hTFIIIB90, two subunits of human RNA Pol III transcription initiation factor IIIB. These data strongly suggest that the hRPC32-hRPC39-hRPC62 subcomplex directs RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and hRPC39.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase III, DNA Directed Polypeptide F (POLR3F) ELISA Kit Customized Service Offer
  1. "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation."Genes Dev. 11:1315-1326(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity."Mol. Cell. Biol. 19:7697-7704(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits."Mol. Cell. Biol. 22:8044-8055(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of winged-helix domain in RNA polymerase III 39kDa polypeptide."Submitted (OCT-2006) to the PDB data bank
  10. "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway."Cell 138:576-591(2009) [PubMed] [Europe PMC] [Abstract]
  11. "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate."Nat. Immunol. 10:1065-1072(2009) [PubMed] [Europe PMC] [Abstract]